Aromatase Inhibitors for Ovulation Induction

Review: aromatase inhibitors for ovulation induction.

CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, ...

Aromatase Inhibitors for Ovulation Induction – the Risk Is Too High Because Currently There Is Insufficient Evidence for Its Efficacy

Aromatase inhibitors versus antioestrogens

Endocrine therapies act by either blocking or downregulating the oestrogen receptor or by reducing oestrogen concentrations around and within the cancer cell. In postmenopausal women, oestrogen suppression is achieved by inhibition of the enzyme aromatase by aromatase inhibitors (AIs). Modern AIs (anastrozole, letrozole and exemestane) are more potent than earlier ones and suppress oestradiol l...

Ovulation induction in perspective.

It has been suggested recently that, in some quarters, IVF be offered as first-line therapy to all infertile couples, regardless of the type of infertility. Hence, the time was thought right to scrutinise the results and complications of ovulation induction for anovulatory infertile couples. In addition to examining the outcome of conventional treatment with gonadotrophins and clomiphene citrat...

Ovulation Induction in Sows

This study reviewed the protocols for ovulation induction in sows by human chorionic gonadotropin (hCG) and gonadotropin releasing hormone (GnRH). In pigs, it was documented that ovulation usually occurred about 70% of the way through oestrus. However, the duration of oestrus in sows highly varies, producing difficulty in performing artificial insemination (AI) in sows at optimal time. In pract...